Structural and Functional Characterization of the Conserved Salt Bridge in Mammalian Paneth Cell α-Defensins
نویسندگان
چکیده
منابع مشابه
Paneth cell α-defensins and enteric microbiota in health and disease
Antimicrobial peptides are major effectors of innate immunity of multicellular organisms including humans and play a critical role in host defense, and their importance is widely recognized. The epithelium of the intestine is the largest surface area exposed to the outer environment, including pathogens, toxins and foods. The Paneth cell lineage of intestinal epithelial cells produces and secre...
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Paneth cells at the base of small intestinal crypts secrete microbicidal α-defensins, termed cryptdins (Crps) in mice, as mediators of innate immunity. Proteomic studies show that five abundant Paneth cell α-defensins in C57BL/6 mice are strain specific in that they have not been identified in other inbred strains of mice. Two C57BL/6-specific peptides are coded for by the Defcr20 and -21 genes...
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15 صفحه اولDifferential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions
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*Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616; †Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226; ‡Department of Biological Sciences, California State University, Los Angeles, CA 90032; §Department of Medicine, David Geffen School of Medicine, University of California, Los Angele...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m604992200